The firm has filed a planning application for a 15 storey, 320,000 sq ft development in Paddington.
The site is located at the junction of Bishop’s Bridge Road and the Grand Union Canal, with the new Hammersmith & City line underground station located to the south.
A canal-level office and retail entrance will be complemented by office space, with a number of “urban realm improvements” being made to the surrounding area.
The station is expected to handle up to 24 per trains per hour when Crossrail opens in 2018.
Crossrail land and property director Ian Lindsay said the development would “play an important role in the continued transformation of Paddington”.
“Crossrail is the first UK rail project to deliver an integrated package of new and improved rail infrastructure alongside high-quality over-site development and public realm improvements which will boost urban regeneration.”
“This development will signal the completion of a further phase in the renaissance of Paddington as a major commercial location.”
The site was designed by Grimshaw, with existing landowners set to deliver the over-site work.
At sites where collaboration agreements are not already in place, Crossrail will procure development partners. These sites include Tottenham Court Road West, Lindsey Street, Fisher Street, Limmo and Woolwich.