The applications are for major alterations to the road network in Runcorn and Widnes as well as for listed building consent to change the traffic flow and road layout on the Silver Jubilee Bridge once the Mersey Gateway bridge has been built.
The 900m long structure proposed to link Runcorn and Widnes.
Tenders for the project are expected to be sought in 2010. The successful contractor will then be appointed in 2011 for the bridge to be operational by 2014.
The development, led by Halton Borough Council, has already attracted interest from Balfour Beatty and Costain as well as overseas firms such as French firm Vinci and BAA owner Ferrovial.