Willmott Dixon has got the green light to build the £28 million Stockwell Park High School in Lambeth.
The new school is the biggest single project so far to be funded under the Building Schools for the Future programme.
It will provide 1200 places for students up to GCSE level, plus a 100-place sixth form and a 15 place special needs unit.
It will see the reintroduction of an amphitheatre which was part of an orphanage previously on the site. It will also include several garden areas, and a sensory area for children with special educational needs.
The company is now carrying out final planning before work begins in February 2008. Construction work will be completed for September 2010.