Ten fire engines and 72 firefighters and officers are attending a blaze at a house under refurbishment on Campden Grove, W8.
The whole of a three-storey building is alight. Part of the roof of a neighbouring property is also on fire.
London Fire Brigade station manager Rhodri Horton, who is at the scene, said: “When crews arrived they were faced with a rapidly developing fire affecting the whole of a three-storey house under refurbishment.
“Firefighters are working hard to bring the fire under control.
“A mother and a daughter from a neighbouring property escaped into their garden. Fire crews used a ladder to get them over a fence and away to safety. Thankfully they were both uninjured.”
The brigade was called at 6.11am.
Fire crews from North Kensington, Kensington, Chelsea, Hammersmith, Paddington, Chiswick and Knightsbridge fire stations are at the scene.
The cause of the fire is not known at this stage.