Keepmoat has been appointed by Manchester City Council to deliver 400 homes in West Gorton in a deal worth £50m.
The scheme has been part-funded with £30m from the Homes & Communities Agency and will deliver 400 new homes for sale.
The homes are part of a wider 10-year regeneration plan for the area, which Manchester council is halfway through delivering.
It will see the demolition of 380 existing homes and the construction of 171 new council houses for affordable rent built by Keepmoat Regeneration.
This will be the first time that Keepmoat has been appointed to build new homes for private sale in Manchester.
Other improvements to the area include the revamp of a site close to the Fujitsu Complex in West Gorton to create a new £10m television production base.
Plan are subject to planning approval for the scheme. If granted, Keepmoat will start on site in the autumn, with the first new homes being occupied in early 2015.