The National Grid has chosen Berkeley’s subsidiary St. James Group to redevelop the Southall Gas Works in west London.
The 80-acre site, next to the M4 and a future Crossrail station, has outline planning permission for 3,750 homes, 525,000 sq ft of commercial and community space and a new primary school.
London mayor Boris Johnson used new planning powers to back the scheme after a public hearing at City Hall in 2010.
The site spreads across the remits of both Ealing and Hillingdon councils. They originally rejected the plans but under the new powers the mayor took over the site to drive it forward.
The project is expected to take 30 years and create several thousands jobs over the course of construction.