Montreaux Developments and Assael Architecture have submitted plans for a 2,000-home site in Ealing.
Montreaux also intends to build offices and retail as part of the mixed-use development, which is estimated to have an overall value of £1bn.
The 2,000 homes will include affordable housing and be located close to the new Crossrail station at Southall.
New infrastructure to be built includes a pedestrian bridge over the rail lines into the station.
The plans were drawn up in six months following Montreaux’s acquisition of the Middlesex Business Centre in December.
The site has been named Margarine Works after a Maypole factory that once operated on the site.
Contractors will be required to retain the Sunrise Radio building and the façade of the Maypole Margarine factory as part of construction.
The developers hope to start on site in the autumn with homes available for sale by 2021.
The project will be delivered in phases, with start on site for the initial stage planned for autumn 2019.