US regeneration specialist Andrew Altman has been named chief executive of the 2012 legacy delivery company.
Mr Altman, who oversaw regeneration projects in Philadelphia and Washington DC, has been tasked with securing lasting legacy for the Olympic Park.
His role will include overseeing the creation of thousands of new homes and jobs, world class sporting, educational and cultural facilities as well as the largest urban park created in Europe for 150 years.
Mayor of London Boris Johnson said: “Transforming this area in the east of London, first into an Olympic Park and then into a thriving new district of London, is one of the biggest ever single regeneration projects seen in Europe.
“To meet this huge challenge requires a big hitter and I believe that, in Andrew, we are getting a big hitter with his impressive record in leading and delivering huge development and regeneration projects in some of the largest cities in the US.”