Plans for 800 new homes have been submitted to East Riding of Yorkshire Council by developers Horncastle Group, Redrow Homes, Riplingham Estates and BAE Systems.
The £100m scheme would create 700 new jobs, according to the developers.
Plans include health and leisure facilities, as well as shops and offices and would require major improvements to the A63 junction at Brough, Elloghton and Welton.
Horncastle Group managing director Ian Hodges said: “Phase one of the Brough relief road has already been constructed and phases two and three will provide an important link to Skillings Lane and BAE Systems.
“Additional highway improvements would also be completed as part of Brough South, including increasing capacity of the roundabout linking Moor Road and Welton Road.”