U+I and Galliard Homes have won a £200m contract to regenerate an industrial estate in the Royal Borough of Greenwich.
The two firms will form a development partnership and redevelop the Westminster Industrial Estate for insurance and investment company Royal London.
Around 450 homes will be created as well as public areas and creative workplaces.
The development is part of the Charlton Riverside opportunity area scheme, for which the Royal Borough of Greenwich has outlined a 15-20-year masterplan.
Around 5,000 homes will be built over 101 ha located within the Thames Gateway in south-east London.
U+I previously secured four further projects in this area.
The developer will took on the Charlton Riverside Industrial Estate area last year in a joint venture with real estate investment firm Proprium.
It has also secured a mixed-use scheme called The Movement in Greenwich town centre; the Telegraph Works residential scheme in Greenwich Peninsula; and the Morden Wharf mixed-use site in Greenwich Peninsula.
U+I has also submitted plans for four regeneration projects worth more than £250m across Kent and Surrey.
The plans could create more than 1,000 homes for rent in Ashford, Maidstone, Swanley and Woking.